Prolotherapy, also known as sclerotherapy is the injection of a special liquid solution into various parts of the spine. It works by causing inflammation and growth of cells between bone and tendon, ligament, or fascia. New collagen tissue forms dense fibrous (scar) tissue. This is thought to help stabilize the spine.

There haven't been many studies done to prove the effectiveness of prolotherapy for chronic low back pain. Early studies are very favorable. Patients who have tried this form of treatment report good results as measured by pain relief. It's unclear how long the benefit lasts.