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I have flare ups of gout off and on. They seem to be triggered by taking the medication (Zyloprim) prescribed by my doctor.

Zyloprim is the brand name of a group of drugs used to treat gout called Allopurinol. Other allopurinol drugs on the market include Allohexal, Allosig, Progout, and Zyloric.

Allopurinol is a drug used to treat conditions arising from excess uric acid. The most common of these is chronic gout. Zyloprim does not take away the acute attacks of gout. But it is useful in preventing recurrence.

Experts think these flare-ups occur when people take the drug because old deposits of crystals from the tissues are released. Since getting rid of the crystal burden is the goal, this response is a good sign the drug is working.

One way to combat this effect is to take daily doses of colchicine. Colchicine has an anti-inflammatory effect. It also inhibits urate crystal from forming deposits.

Understanding when, how, and why to take your prescribed medications is essential for the management of gout and prevention of flare-ups. If you do not fully understand your current drug regimen, talk with your doctor. A well-educated patient with gout has a better chance of minimizing painful episodes by using medications appropriately.


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