Patient Information Resources


Centre for Orthopaedics
Suite 10-33/34/35 Mount Elizabeth Novena Specialist Centre
38 Irrawaddy Road
Singapore, 329563, Singapore
Ph: (65) 6684 5828
Fax: (65) 6684 5829
sharon@cfo.com.sg






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Child Orthopedics
Elbow
Foot
Fractures
General
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Hip
Knee
Pain Management
Shoulder
Spine - Cervical
Spine - General
Spine - Lumbar
Spine - Thoracic
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Is it possible that some medications are not being approved because some people are non-responders versus the drug not being beneficial?

Yes, because a drug may be beneficial to a small proportion of people who are responders, present study designs may dilute results due to the non-responders. The authors of a recent study suggest the use of a study design called enriched enrolment with randomised withdrawal, EERW. In this study design, subjects are tried on a drug first, and only those who have a positive response are then randomised to study it further.

References:

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