Measuring the total number of fractures and how severe they are shows if the problem is widespread in the body. Systemic (whole body) bone fragility is a serious medical problem that should be treated. Treatment can help prevent more fractures and other problems.

Recent studies have shown that some women with knee osteoarthritis later develop vertebral compression fractures. Researchers think systemic bone fragility may have a "latent" effect. This means the overall bone weakness occurs much later than the osteoarthritis. Finding bone problems early is important for treatment.