Scientists are finding that because of genetic differences, usually in the ability of the body to breakdown or bind certain molecules, some people can respond to a drug when others do not. Those who are able to benefit from a drug are called responders. Those that do not are called non-responders.

H.J. McQuay et al. Enriched enrolment with randomised withdrawal (EERW): Time for a new look at clinical trial design in chronic pain. Pain 2008. Volume 135. Pp. 217-220.

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