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What is the worst that can happen with complex regional pain syndrome?

People with complex regional pain syndrome (CRPS) vary with the severity of their symptoms. The pain, skin temperature change, and muscle weakness can be mild or become so severe that amputation is required.

Some people find that the symptoms do go away on their own, while some can manage their symptoms with symptom-specific medications. Other treatments that may be tried include physical therapy, nerve blocks, spinal cord stimulation, and drug pumps to deliver opioids (narcotics) and local anesthetics directly into the spinal cord.

Reference: 

Alexander G. Munts, MD, et al. Analysis of Cerebrospinal Fluid Inflammatory Mediators in Chronic Complex Regional Pain Syndrome Related Dystonia. In Clinical Journal of Pain. January 2008. Vol. 24. No. 1.

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