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Is there a significant risk of mortality following vertebral compression fracture?

Yes, a recent study evaluated available literature. The authors found that the mortality rate ranged between 23 and 67 percent.

Reference: 

W.F. Lavele et al. Effect of kyphoplasty on survival after vertebral compression fractures. Spine. September 2008. Volume 8. Issue 5. Pp. 763-769

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