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If someone has pressure on the nerves in the spine, can they be permanently damaged?

Yes, if there is heavy pressure and/or prolonged pressure on the nerve roots in the spine, it is entirely possible that the nerves become permanently damaged. If, however, the problem is removed as soon as possible, there is a chance that some recovery occurs.

Reference: 

Alex Gitelman, MD, et al. Cauda Equina Syndrome: A Comprehensive Review. In The American Journal of Orthopedics. December 2008. Vol. 37. no. 11. Pp. 556-562.

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